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There were no significant differences between the treatment and placebo groups with regard to primary or secondary endpoints, and the results did not identify any clinical benefits of selenium supplementation in high-risk cardiac surgery patients

Genomic studies and animal models have indicated that Se intake influences the expression of selenoprotein genes and pathways key to colorectal carcinogenesis such as the antioxidant response, immune and inflammatory pathways (including NF-kB and Nrf 2 signaling), the Wnt signaling pathway, protein synthesis pathway (Ye et al., 2021)

M., Del Giudice, F

Monitor side effects and modify with a doctor to optimize benefits and reduce risks

These trials tracked numerous safety parameters and laboratory values, but vitamin b12 levels were not routinely monitored or reported in the published results